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Crystalloid lysozyme inclusions in Paneth cells of vitamin A-deficient rats |
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| Authors: | Martin J Koch Hans K Biesalski Eckart Stofft Harald Weiser Helmut E Gabbert Hans-P Dienes Burkard Schulz-Dobrick Karl H Bässler |
| Institution: | (1) Department of Anatomy, University of Mainz, Germany;(2) Department of Physiological Chemistry, University of Mainz, Germany;(3) Department of Pathological Anatomy, University of Mainz, Germany;(4) Department of Mineralogy, University of Mainz, Germany;(5) Research Department, Hoffmann-La Roche & Co. Ltd., Basle, Switzerland;(6) Department of Anatomy, University of Mainz, Saarstrasse 21, D-6500 Mainz, FRG |
| Abstract: | Summary The effect of vitamin A-deficiency on jejunal Paneth cells in rats was investigated. Crystalloid particles were observed in secretion granules of Paneth cells from 6 out of 8 rats with vitamin A-deficiency. The particles were similar to those found in Paneth cells under other experimental conditions. Using an immuno-electron-microscopic technique we demonstrated a clear lysozyme immunoreactivity of these particles. In 2 vitamin A-deficient rats tubular structures have been detected in addition to the crystalloid particles. Crystalloid particles or tubular structures were not detectable in a control group of 8 vitamin A-supplemented rats. The morphological alterations of Paneth cells may be correlated to an impaired local immunity of the intestine during vitamin A-deficiency.This work represents a portion of a doctoral thesis presented by M.J. Koch in partial fullfillment for the degree of medical doctor |
| Keywords: | Vitamin A-deficiency Paneth cells Crystalloid lysozyme Tubular structures Intestinal local immunity Electron microscopy Rat (Sprague-Dawley) |
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