Selective uptake of alloxan by pancreatic B-cells |
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| Authors: | F K Gorus W J Malaisse D G Pipeleers |
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| Institution: | Department of Metabolism and Endocrinology, Vrije Universiteit Brussel, B-1090 Brussels, Belgium;Laboratory of Experimental Medicine, Université Libre de Bruxelles, B-1000 Brussels, Belgium |
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| Abstract: | Alloxan rapidly binds to or accumulates in pancreatic B-cells as distinct from non-B-cells. The selective uptake of this cytotoxic agent by the insulin-producing B-cells might account for its well-known diabetogenic effect. |
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