Effects of ketamine on the cholecystokinin,somatostatin, substance P,and thyrotropin releasing hormone in discrete regions of rat brain |
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| Authors: | K. Pongdhana N. Ogawa Y. Hirose T. Ono F. Kosaka A. Mori |
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| Affiliation: | (1) Department of Anesthesiology, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama 700, Japan;(2) Institute for Neurobiology, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama 700, Japan |
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| Abstract: | Intraperitoneal injection of ketamine (100 mg/kg body weight) significantly reduces the levels of cholecystokinin (CCK) somatostatin (SRIF), and substance P (SP)-like immunoreactivity in various regions of rat brain. No significant change in thyrotropin releasing hormone (TRH)-like immunoreactivity was observed. Neuropeptide systems may be involved in the neuropharmacologic effects of ketamine. |
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| Keywords: | Ketamine cholecystokinin somatostatin substance P |
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