| 紫杉醇生物合成相关酶类的研究进展 |
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| 引用本文： | 贾宁,仇燕,王刚.紫杉醇生物合成相关酶类的研究进展[J].生物学杂志,2002,18(6):9-12. |
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| 作者姓名： | 贾宁 仇燕 王刚 |
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| 作者单位： | 河北师范大学生命科学学院,石家庄,050016 |
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| 基金项目： | 河北省自然科学基金 (30 0 1 62 ) |
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| 摘 要： | 紫杉醇是红豆杉属植物次生代谢产物之一，是近20年来抗癌药物研究领域的重要发现。弄清楚紫杉醇合成途径和相关酶的反应可以从根本上大大提高紫杉醇的产量。综述近几年来紫杉醇生物合成途径中相关酶的研究工作，包括已经得到相应cDNA克隆的紫杉二烯合成酶，细胞色素P450氧化酶和3个紫杉烷的乙酰转移酶，由于GGPP是紫杉醇合成的必需前体，HMGR和GGPP合成酶的相关情况也有简述。
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| 关 键 词： | 紫杉醇 生物合成 相关酶类 研究进展 |
| 文章编号： | 1008-9632(2002)06-0009-04 |
Progress of the studies on enzymes in taxol biosynthesis |
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| JIA Ning,QIU Yan,WANG Gang.Progress of the studies on enzymes in taxol biosynthesis[J].Journal of Biology,2002,18(6):9-12. |
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| Authors: | JIA Ning QIU Yan WANG Gang |
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| Abstract: | Taxol is the product of yew tree that has been considered the important discover in twenty years:The yield of taxol could be improved greatly if the biosythesis of taxol and the characteristic of the enzymes were made clearly.The studies of enzymes in Taxol biosynthesis including taxadienesynthase cytychrome P 450 oxygenase and three acetyltransferases were summarized.The properties of Taxus geranylgeranyl dipnpsphate synthase and HMGR were also described because geranylgeranyl diphosphate was the indispensable precurse for taxol. |
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| Keywords: | taxol biosynthesis enzyme |
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