| 急性巨细胞病毒感染导致新生豚鼠脾细胞亚群的定量改变 |
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| 引用本文： | 郑志明,Griffith B·P.急性巨细胞病毒感染导致新生豚鼠脾细胞亚群的定量改变[J].病毒学报,1987(2). |
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| 作者姓名： | 郑志明 Griffith B·P |
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| 作者单位： | 湖北医学院病毒研究所
(郑志明)，耶鲁大学医学院实验医学系(Griffith B·P) |
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| 摘 要： | 新生豚鼠皮下接种豚鼠巨细胞病毒(GPCMV)后,导致脾脏GPCMV急性感染,脾脏肿大,脾细胞增生,计算表明,脾T淋巴细胞,B淋巴细胞、吞噬细胞数显著高于正常动物,接种病毒后第5天即可在脾细胞检出高滴度感染性病毒(达2.5 log10 TCID50/10~7细胞),其中,主要是脾B淋巴细胞、T淋巴细胞和巨噬细胞携带病毒。
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| 关 键 词： | 豚鼠巨细胞病毒 淋巴细胞 吞噬细胞 |
QUANTITATIVE ALTERATION OF SPLENIC CELL SUBPOPULATION IN NEWBORN GUINEA PIGS WITH ACUTE CYTOMEGA LOVIRUS INFECTION |
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| Zheng zhiming Griffith B. P. Virus Research Institute,Hubei Medical College,Wuhan.QUANTITATIVE ALTERATION OF SPLENIC CELL SUBPOPULATION IN NEWBORN GUINEA PIGS WITH ACUTE CYTOMEGA LOVIRUS INFECTION[J].Chinese Journal of Virology,1987(2). |
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| Authors: | Zheng zhiming Griffith B P Virus Research Institute Hubei Medical College Wuhan |
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| Institution: | Zheng zhiming Griffith B. P. Virus Research Institute,Hubei Medical College,Wuhan.Department of Laboratory Medicine,Yale University School of Medicine,New Haven,CT 06510 USA. |
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| Abstract: | Subcutaneous inoculation of neonatal guinea pigs with guinea pig cytome-galovirus ( GPCMV ) resulted in acute infection of spleen with splenomegaly and splenic cell proliferation. It has been shown that the number of splenic T lymphocytes, B lymphocytes, and phagocytes were significantly higher in GPCMV-infected animals than in age-matched controls. Infectious virus could be recovered from splenic cells with a titer of 2.5 log10 TCID50 /107 cells on day 5 postinoculation. Moreover, virus was demonstrated to be associated with both T and B lymphocytes and macrophages in this study. |
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| Keywords: | Guinea pig cytomegalovirus Lymphocyte Phagocyte |
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