Opposite and mutually incompatible structural requirements of type-2 casein kinase and cAMP-dependent protein kinase as visualized with synthetic peptide substrates |
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| Authors: | L A Pinna F Meggio F Marchiori G Borin |
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| Affiliation: | Laboratory of Cell and Molecular Biology of the Institute of Experimental Medicine, CNR, V.le R. Elena, 324, 00161 Rome, Italy;Faculty of Sciences of the University of Naples, Naples, Italy |
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| Abstract: | Mouse 3T3 cells were grown and synchronized in monolayer with the double thymidine block. Their infection with SV40 took place continuously during the cellular cycle. However, integration of viral DNA into host cell DNA occurred preferentially during the S phase. Phase G1 appeared to be necessary for virus-cell DNA recombination in S phase. Phase G2 did not alter the stability of the integrated viral genome. |
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| Keywords: | Integration SV40 DNA Cell cycle 3T3 cell |
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