How do Ca2+ ions pass through the sarcoplasmic reticulum membrane |
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| Authors: | Elisabeth Mintz Florent Guillain |
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| Affiliation: | (1) Département de Biologie Cellulaire et Moléculaire, Centre d'Etude de Saclay, Commissariat à l'Energie Atomique and Unité de Recherche 1290 Associée au Centre National de la Recherche Scientifique, Section de Biophysique des Protéines et des Membranes, 91191 Gif-sur-Yvette Cedex, France |
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| Abstract: | We propose an overview of the mechanism of Ca2+ transport through the sarcoplasmic reticulum membrane via the Ca2+-ATPase. We describe cytoplasmic calcium binding, calcium occlusion in the membrane and lumenal calcium dissociation. A channel-like structure is discussed and related to structural data on the membranous domain of the Ca2+-ATPase.Abbreviations SR Sarcoplasmic Reticulum - AMPPNP adenylyl-imidodiphosphate - AMPPCP adenylyl ( , -methylene)-diphosphonate - FITC fluorescein 5 -isothiocyanate - NBD 4-nitrobenzo-2-oxa-1,3-diazole - DCCD dicyclohexylcarbodiimide |
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| Keywords: | ATPase calcium sarcoplasmic reticulum |
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