Distribution of IP25 in chromatin and its possible involvement in chromatin condensation |
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| Authors: | R Gjerset F Ibarrando S Saragosti H Eisen |
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| Affiliation: | 1. Groupe C.N.R.S. 33, Laboratoire de Physiopathologie Générale et Comparée, Université Claude-Bernard, 69622-Villeurbanne Cédex, France.;2. Départment de Pharmacologie Cellulaire et Moléculaire, I.N.S.E.R.M., Unité 50, I.C.I.G., 14-16, avenue Paul-Vaillant Couturier, 94800-Villejuif, France;3. I.N.S.E.R.M., F.R.A. 24, Centre Léon Bérard, 69-Lyon, France. |
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| Abstract: | Friend leukaemic cells (FLC) were induced to differentiate with dimethyl sulfoxyde (DMSO), hexamethylenbis-acetamide (HMBA) and sodium butyrate (SB) and the phospholipid composition was analyzed. The phospholipid composition of differentiated cells differed from that of non differentiated cells and also varied according to inducer. The ratios of the percentage of phosphatidyl choline (PC) to that of phosphatidyl ethanolamine (PE) or sphingomyelin (SPH) increased by about 2-fold in DMSO or SB induced FLC. These ratios did not vary in HMBa induced FLC. Furthermore the fatty acid composition of PC and PE obtained from differentiated cells varied according to the inducer. Although these changes appeared to be related to the inducers, it can not be excluded that the differentiated state also contributes to these changes. |
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| Keywords: | To whom request for reprints should be addressed. |
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