Prostaglandin E and F levels in mouse epidermis are increased by tumor-promoting phorbol esters |
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Authors: | C L Ashendel R K Boutwell |
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Institution: | McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, Wisconsin 53706 USA |
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Abstract: | After topical application of tumor-promoting phorbol esters, immunoreactive prostaglandins E and F in mouse epidermis were increased several-fold over basal levels. The increases were doubled by 3 hours and lasted until 5 days after phorbol ester treatment. The activities of various phorbol esters for increasing epidermal prostaglandin levels paralleled the tumorpromoting activities of these compounds. Topical pretreatment with nonsteroidal anti-inflammatory drugs inhibited the effect of phorbol esters on epidermal prostaglandin levels. |
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