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Formulation of novel lipid-coated magnetic nanoparticles as the probe for in vivo imaging |
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| Authors: | Huey-Chung Huang Po-Yuan Chang Karen Chang Chao-Yu Chen Chung-Wu Lin Jyh-Horng Chen Chung-Yuan Mou Zee-Fen Chang Fu-Hsiung Chang |
| Affiliation: | (1) Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan;(2) Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan;(3) Department of Life Science, College of Science and Engineering, Fu-Jen Catholic University, Taipei, Taiwan;(4) Department of Pathology, College of Medicine, National Taiwan University, Taipei, Taiwan;(5) Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan;(6) Department of Chemistry, College of Science, National Taiwan University, Taipei, Taiwan |
| Abstract: | BackgroundApplication of superparamagnetic iron oxide nanoparticles (SPIOs) as the contrast agent has improved the quality of magnetic resonance (MR) imaging. Low efficiency of loading the commercially available iron oxide nanoparticles into cells and the cytotoxicity of previously formulated complexes limit their usage as the image probe. Here, we formulated new cationic lipid nanoparticles containing SPIOs feasible for in vivo imaging. |
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