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The origin and ultrastructural characteristics of corticotropin-releasing factor (CRF)-immunoreactive nerve fibers in the posterior pituitary of the rat |
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| Authors: | István Lengvári MD Zsolt Liposits Sándor Vigh Andrew V Schally Béla Flerkó |
| Institution: | (1) Department of Anatomy, University Medical School, Pécs, Hungary;(2) Endocrine and Polypeptide Laboratory, Veterans' Administration Medical Center, USA;(3) The Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA;(4) Dept. of Anatomy, University Medical School, 7643 Pécs, Szigeti ut 12, Hungary |
| Abstract: | Summary A fine network of corticotropin-releasing factor (CRF)-immunopositive fibers was found in the posterior lobe of the pituitary of the rat. The intermediate and distal lobes were free of CRF-immunoreactivity. Varicose, terminal-like axons were frequently observed around capillary vessels. Surgical isolation of the paraventricular nuclei resulted in a complete disappearance of CRF-immunoreactive fibers from the posterior lobe. CRF-immunopositive fibers show the general characteristics of peptidergic axons. These ultrastructural observations support the idea that CRF is secreted into capillary vessels. |
| Keywords: | CRF immunohistology Paraventricular nuclei Pituitary gland pars nervosa Electron microscopy Rat |
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