Coordinate regulation of RARgamma2, TBP, and TAFII135 by targeted proteolysis during retinoic acid-induced differentiation of F9 embryonal carcinoma cells |
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| Authors: | Lucia Perletti Eliezer Kopf Lucie Carré Irwin Davidson |
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| Institution: | 1. Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP. B.P. 163-67404 Illkirch Cédex C.U., de Strasbourg, France
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| Abstract: | Background Treatment of mouse F9 embryonal carcinoma cells with all-trans retinoic acid (T-RA) induces differentiation into primitive endodermal type cells. Differentiation requires the action of the receptors for all trans, and 9cis-retinoic acid (RAR and RXR, respectively) and is accompanied by growth inhibition, changes in cell morphology, increased apoptosis, proteolytic degradation of the RARγ2 receptor, and induction of target genes. |
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