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Pan-Cancer analyses of Necroptosis-Related genes as a potential target to predict immunotherapeutic outcome |
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| Authors: | Zheng Zhou Jiajun Wu Wenli Ma Feilin Dong Jiafeng Wang |
| Institution: | 1. Bengbu Medical College Graduate School, Bengbu, China;2. Bengbu Medical College Graduate School, Bengbu, China
Department of Head and Neck Surgery, Centre of Otolaryngology-Head and Neck Surgery, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China Contribution: Conceptualization (supporting), Project administration (supporting);3. Bengbu Medical College Graduate School, Bengbu, China Department of Head and Neck Surgery, Centre of Otolaryngology-Head and Neck Surgery, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China Contribution: Data curation (supporting), Investigation (supporting);4. Zhejiang Provincial Key Laboratory of Diagnosis and Treatment of Endocrine Gland Diseases, Hangzhou, China Contribution: Funding acquisition (supporting), Supervision (supporting);5. Department of Head and Neck Surgery, Centre of Otolaryngology-Head and Neck Surgery, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China |
| Abstract: | Necroptosis is a unique programmed death mechanism of necrotic cells. However, its role and specific mechanism in cancer remain unclear, and a systematic pan-cancer analysis of necroptosis is yet to be conducted. Thus, we performed a specific pan-cancer analysis using The Cancer Genome Atlas and Genotype-Tissue Expression databases to analyse necroptosis expression in terms of cancer prognosis, DNA methylation status, tumour mutative burden, microsatellite instability, immune cell infiltration in different types of cancer and molecular mechanisms. For the first time, we explored the correlation between necroptosis and immunotherapy prognosis. Thus, our study provides a relatively comprehensive understanding of the carcinogenicity of necroptosis in different types of cancer. It is suggested that necroptosis can be used to evaluate the sensitivity of different patients to immunotherapy and may become a potential target for tumour immunotherapy. |
| Keywords: | cancer immunotherapy mutation necroptosis tumour microenvironment |