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Advances in the role of SWI/SNF complexes in tumours |
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| Authors: | Ziwei Li Jiumei Zhao Yu Tang |
| Institution: | 1. Chongqing Health Center for Women and Children, Women and Children's Hospital of Chongqing Medical University, Chongqing, China
Contribution: Data curation (equal), Funding acquisition (equal), Software (equal);2. Chongqing Nanchuan District People's Hospital, Chongqing, China Contribution: Data curation (equal), ?Investigation (equal), Resources (equal), Software (equal);3. The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Kunming, China |
| Abstract: | Cancer development is a complex process involving both genetic and epigenetic changes. The SWI/SNF (switch/sucrose non-fermentable) chromatin remodelling complex, one of the most studied ATP-dependent complexes, plays an important role in coordinating chromatin structural stability, gene expression and post-translational modifications. The SWI/SNF complex can be classified into BAF, PBAF and GBAF according to their constituent subunits. Cancer genome sequencing studies have shown a high incidence of mutations in genes encoding subunits of the SWI/SNF chromatin remodelling complex, with abnormalities in one or more of these genes present in nearly 25% of all cancers, which indicating that stabilizing normal expression of genes encoding subunits in the SWI/SNF complex may prevent tumorigenesis. In this paper, we will review the relationship between the SWI/SNF complex and some clinical tumours and its mechanism of action. The aim is to provide a theoretical basis to guide the diagnosis and treatment of tumours caused by mutations or inactivation of one or more genes encoding subunits of the SWI/SNF complex in the clinical setting. |
| Keywords: | diagnosis molecular mechanism SWI/SNF complex treatment tumour |