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Selenium in combination with a tomato lipid extract as a therapy for benign prostatic hyperplasia and its alterations in rats with induced BPH |
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| Authors: | David Julian Arias-Chávez Patrick Mailloux-Salinas Jessica Ledesma Aparicio Elihu Campos-Pérez Omar Noel Medina-Campos José Pedraza-Chaverri Guadalupe Bravo |
| Institution: | 1. Departmento de Farmacobiología, Centro de Investigación y de Estudios Avanzados del IPN, Sede Sur, Mexico City, Mexico;2. Departmento de Farmacobiología, Centro de Investigación y de Estudios Avanzados del IPN, Sede Sur, Mexico City, Mexico
Contribution: Formal analysis (equal), Methodology (equal), Supervision (equal);3. Departmento de Farmacobiología, Centro de Investigación y de Estudios Avanzados del IPN, Sede Sur, Mexico City, Mexico Contribution: Methodology (equal), Writing - original draft (equal);4. Departamento de Patología, ISSSTE, Hospital General Dra. Matilde Petra Montoya Lafragua, Mexico City, Mexico Departamento de Patología, Hospital Ángeles Lindavista, Mexico City, Mexico Contribution: Methodology (equal), Supervision (equal), Visualization (equal);5. Laboratorio F-315, Departamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México, Mexico City, Mexico Contribution: Methodology (equal), Writing - review & editing (equal);6. Laboratorio F-315, Departamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México, Mexico City, Mexico Contribution: ?Investigation (equal), Methodology (equal), Writing - review & editing (equal) |
| Abstract: | Benign prostatic hyperplasia (BPH) is the most common adenoma in old men. Tomatoes are a rich source of bioactive compounds that, as well as selenium (Se), possess antioxidant and antiproliferative activity. The aim was to evaluate the therapeutic effect of Se in combination with a tomato extract in aged rats with BPH. Aged male Wistar rats were divided in the following groups (n = 10 rats/group): Control (C), BPH, BPH + Finasteride (BPH + F), BPH + Tomato Lipidic Extract (BPH + E), BPH + Selenium (BPH + S) and BPH plus E plus S (BPH + E + S). After 4 weeks of treatment, prostate weight, diuresis, antioxidants enzymes, prooxidants and inflammatory markers, growth factors and androgens were determined. BPH + E + S reduced prostate weight by 59.29% and inhibited growth by 99.35% compared to BPH + F which only decreased weight and inhibited growth by 15.31% and 57.54%, respectively. Prooxidant markers were higher with BPH + F (49.4% higher vs. BPH), but BPH + E + S decreased these markers (94.27% vs. BPH) and increased antioxidant activity. Finally, diuresis was higher with the BPH + E + S combination and markers of inflammation and growth factors were significantly lower with respect to BPH + F. Our findings provide a beneficial and protective therapeutic option of E + S directed against androgens, oxidative stress and inflammation that regulates cell proliferation in the prostate gland. |
| Keywords: | benign prostatic hyperplasia dihydrotestosterone finasteride inflammation oxidative stress PSA selenium testosterone tomato |