Phialomyces macrosporus: Chemical Constituents,Antimicrobial Activity and Complete NMR Assignments for the 7,7′‐Biphyscion |
| |
Authors: | Mauricio da Silva Brando Lucas Silva Abreu Regina Geris |
| |
Institution: | Mauricio da Silva Brandão,Lucas Silva Abreu,Regina Geris |
| |
Abstract: | Five known secondary metabolites, chrysophanol ( 1 ), 7,7′‐biphyscion ( 2 ), secalonic acid D ( 3 ), mannitol ( 4 ) and trehalose ( 5 ) were isolated for the first time from the extracts of the fungus Phialomyces macrosporus. Their structures were elucidated by NMR methods (1D and 2D NMR analysis), optical activity and ESI‐MS. Complete 1H and 13C assignments were performed for compound 2 . The antimicrobial activity was evaluated by serial microdilution assay for compounds 2 and 3 and results showed that compound 3 exhibited a significant growth inhibition at concentrations of 15.6 mg/ml (S. aureus and S. choleraesius) and 0.97 mg/mL (B. subtilis), comparable to the positive control. |
| |
Keywords: | Phialomyces macrosporus chrysophanol 7 7′ -biphyscion secalonic acid D mannitol trehalose antimicrobial activity biological activity |
|
|