| 毒黄素对黄嘌呤氧化酶作用的影响 |
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| 引用本文： | 任维栋,赵乃昕,苑永华,刘进升,刘殿珍.毒黄素对黄嘌呤氧化酶作用的影响[J].生物化学与生物物理进展,1992,19(2):119-122. |
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| 作者姓名： | 任维栋 赵乃昕 苑永华 刘进升 刘殿珍 |
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| 作者单位： | 潍坊医学院;潍坊医学院;潍坊医学院;潍坊医学院;潍坊医学院 |
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| 摘 要： | 利用从椰毒假单胞菌(Pseudomona cocovenenans)中所分离提取的毒黄素(toxoflavin)对黄嘌呤氧化酶(EC.1、2 3、2)作用的动力学试验表明,毒黄素是此酶的非必需激活剂,而且对以次黄嘌呤为底物的反应的激活作用明显高于以黄嘌呤为底物的反应。此激活作用属于部分混合型。这一结果为探寻毒黄素对人体的致毒机理提供了一条重要线索。
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| 关 键 词： | 毒黄素 黄嘌呤氧化酶 部分混合型激活作用 |
| 收稿时间： | 1990/10/15 0:00:00 |
| 修稿时间： | 1990/12/9 0:00:00 |
EFFECT OF TOXOFLAVIN ON THE ACTION OF XANTHINE OXIDASE |
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| Ren Weidong,Zhao Naixin,Yun Yunghu,Liu Jinsheng and Liu Dianzhen.EFFECT OF TOXOFLAVIN ON THE ACTION OF XANTHINE OXIDASE[J].Progress In Biochemistry and Biophysics,1992,19(2):119-122. |
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| Authors: | Ren Weidong Zhao Naixin Yun Yunghu Liu Jinsheng and Liu Dianzhen |
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| Institution: | Weifang Medical College;Weifang Medical College;Weifang Medical College;Weifang Medical College;Weifang Medical College |
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| Abstract: | The kinetic studies of effect of toxoflavine on the action of xanthine oxidase (ECl, 2,3,2) which was extracted from Pseudomona cocovenenans showed that toxoflavin was nonessential activator for the enzyme, and the activation in condition of hypoxanthine as substrate was more marked than xanthine. The activation obeyed the partial activation type. These results provide us a clue for searching toxic mechanism of toxoflavin for human. |
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| Keywords: | toxoflavin xanthine oxidase partial activation |
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