Membrane potential measurements in isolated rat liver plasma membrane vesicles: effect of transmembrane ion concentration gradients |
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| Authors: | T Thalhammer M Peterlik J Graf |
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| Institution: | Institute of General and Experimental Pathology, University of Vienna, Austria. |
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| Abstract: | In isolated basolateral and canalicular rat liver plasma membrane vesicles the membrane potential (measured with DiS-C2 (5] varied with transmembrane concentration gradients of Na+, K+ and Cl- revealing the following ion permeabilities: basolateral vesicles: PNa/PK: 0.76, PCl/PK: 0.45 and canalicular vesicles: PNa/PK: 0.69, PCl/PK: 0.56. The data indicate a permselectivity of PK greater than PNa greater than PCl for both membranes. |
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