Role of neurotransmitters and neuropeptides in the control of gonadotropin release: A review |
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Authors: | E Vijayan |
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Institution: | (1) School of Life Sciences, University of Hyderabad, 500134 Hyderabad, India |
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Abstract: | Rapid progress has been recorded recently in the understanding of the role of neuro-transmitters and neuropeptides in the
control of reproduction and on their apparent potential in the regulation of fertility. Peptides, as well as monoamines, are
important in the control of lutinizing hormone releasing hormone and gonadotropin release. The input from brainstem noradrenergic
neurons as well as dopamine mediated stimulated release of lutinizing hormone. In addition considerable evidence exist for
the occurrence of a specific follicle stimulating hormone-releasing factor. A large number of brain peptides affect the secretion
of lutinizing hormone releasing hormone and the endogenous opioid peptides appear to have a physiologically important function
in restraining the influence on lutinizing hormone releasing hormone release under most circumstances. Vasoactive intestinal
peptide and substanceP stimulate whereas cholecystokinin, neurotensin, gastrin, secretin, somatostatin α-melanosite stimulating hormone and vasotocin
inhibit lutinizing hormone release. Of the inhibitory peptides, cholecystokinin and arg-vasotocin are the most potent. Inhibin
injected into the ventricle selectively suppresses follicle stimulating hormone release by a hypothalamic action. Thus the
control of gonadotropin release is complex and a number of aminergic and peptidergic transmitters are involved. |
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Keywords: | Neurotransmitters neuropeptides LHRH gonadotropin release |
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