Allocation of the suppressive activity of normal peripheral blood lymphocytes induced by diffusion chamber culture and Con A stimulation to the G2 phase of the cell cycle |
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| Authors: | K Pachmann U Pachmann R Penning |
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| Affiliation: | 1. Alimentiv Inc., 100 Dundas Street, Suite 200, London, ON, Canada;2. Department of Microbiology and Immunology, Laboratory of Allergy and Clinical Immunology, KU Leuven, Herestraat 49, Leuven, Belgium;3. Translational Research Center for Gastrointestinal Disorders (TARGID), Department of Chronic Diseases & Metabolism (CHROMETA), KU Leuven, Herestraat 49, Leuven, Belgium;4. Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, Herestraat 49, Leuven, Belgium;5. Departments of Medicine and Epidemiology and Biostatistics, Western University, 1151 Richmond St, London, ON, Canada;6. Inflammatory Bowel Disease Center, Division of Gastroenterology, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, USA;1. Biomarker Sciences, Gilead Sciences Inc., Foster City, CA, USA;2. Clinical Bioinformatics & Exploratory Analytics, Gilead Sciences Inc., Foster City, CA, USA |
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| Abstract: | ![]()
Peripheral blood mononuclear cells stimulated either by diffusion chamber culture or by a high Con A concentration exhibit suppressive activity under conditions where no increase in cell number takes place. Instead an accumulation of large cells is observed which, according to their DNA contents, are classified as cells in the G2 phase of the cell cycle. By elutriation separation the suppressive activity is shown to be confined to this cell cycle phase. |
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