| RNA干扰的研究进展 |
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| 引用本文： | 董艳珍,李关荣.RNA干扰的研究进展[J].生物技术通讯,2004,15(1):60-62. |
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| 作者姓名： | 董艳珍 李关荣 |
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| 作者单位： | 西南农业大学,农学与生命科学学院,重庆,400716 |
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| 摘 要： | RNA干扰是指外源双链RNA进入细胞后引起与其同源的mRNA特异性降解的现象，它是真核生物在长期进化中形成的一种保守的防御机制，对真核生物有着重要的意义，它参与真核生物抵御病毒侵染、阻断转座子的异常活动，调控基因表达。RNA干扰已成为一种进行基因功能分析的强有力的工具，并有望成为最有潜力的基因干预治疗方法。
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| 关 键 词： | RNA干扰 双链RNA 基因沉默 mRNA 基因治疗 |
| 文章编号： | 1009-0002(2004)01-0060-03 |
| 修稿时间： | 2003年5月20日 |
Advances in RNA interference |
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| DONG Yan-zhen,LI Guan-rong College of Agronomy and Life Sciences,Southwest Agricultural University,Chongqing,China.Advances in RNA interference[J].Letters in Biotechnology,2004,15(1):60-62. |
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| Authors: | DONG Yan-zhen LI Guan-rong College of Agronomy and Life Sciences Southwest Agricultural University Chongqing China |
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| Institution: | DONG Yan-zhen,LI Guan-rong College of Agronomy and Life Sciences,Southwest Agricultural University,Chongqing400716,China |
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| Abstract: | RNA interference(RNAi)is an evolutionarily conserved eukaryotic adaptive response that leads to the specific degradation of target mRNA species in response to cellular exposure to homologous double-stranded RNA molecules.RNAi is to eukaryote important in that it mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids,and regulates the expression of protein-coding genes.RNAi is now a powerful instrument for functional genomic analyses and will be a potentially useful method in highly specific dsRNA based gene-silencing therapeutics. |
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| Keywords: | RNA interference dsRNA gene silence mRNA gene therapy |
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