| 革兰氏阴性菌亚铁离子转运系统的组成及作用机制 |
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| 引用本文： | 冯言,刘马峰,程安春.革兰氏阴性菌亚铁离子转运系统的组成及作用机制[J].微生物学报,2016,56(7):1061-1069. |
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| 作者姓名： | 冯言 刘马峰 程安春 |
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| 作者单位： | 四川农业大学动物医学院, 预防兽医研究所, 四川 成都 611130;四川农业大学动物医学院, 禽病防治中心, 四川 成都 611130;四川农业大学动物疫病与人类健康四川省重点实验室, 四川 成都 611130,四川农业大学动物医学院, 预防兽医研究所, 四川 成都 611130;四川农业大学动物医学院, 禽病防治中心, 四川 成都 611130;四川农业大学动物疫病与人类健康四川省重点实验室, 四川 成都 611130,四川农业大学动物医学院, 预防兽医研究所, 四川 成都 611130;四川农业大学动物医学院, 禽病防治中心, 四川 成都 611130;四川农业大学动物疫病与人类健康四川省重点实验室, 四川 成都 611130 |
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| 基金项目： | 国家自然科学基金(31302131);高等学校博士学科点专项科研基金(20135103120006);中国博士后基金(2014M552378);四川省博士后特别资助基金 |
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| 摘 要： | 几乎所有细菌的生长都离不开铁元素。在有氧的环境中,三价铁离子几乎无法被细菌直接利用。但是在宿主胃肠道中,铁元素主要以可溶性的亚铁离子形式存在,它们可通过革兰氏阴性菌外膜直接进入胞周质,在周质通过亚铁离子转运系统,将铁离子转运至胞浆供细菌利用。绝大多数阴性菌主要是通过Feo转运系统利用亚铁离子,大肠杆菌的Feo转运系统由feoA、feoB和feoC3个基因组成。除Feo转运系统外,还发现Yfe转运系统、Efe转运系统、Sit转运系统等。本文重点介绍革兰氏阴性菌Feo转运系统的组成及作用机制,以期为进一步研究细菌亚铁离子的转运机制提供参考。
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| 关 键 词： | 革兰氏阴性菌 亚铁离子 Feo转运系统 |
| 收稿时间： | 9/8/2015 12:00:00 AM |
| 修稿时间： | 2015/10/24 0:00:00 |
Component and functional mechanism of the ferrous iron acquisition system in gram-negative bacteria-A review |
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| Yan Feng,Mafeng Liu and Anchun Cheng.Component and functional mechanism of the ferrous iron acquisition system in gram-negative bacteria-A review[J].Acta Microbiologica Sinica,2016,56(7):1061-1069. |
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| Authors: | Yan Feng Mafeng Liu and Anchun Cheng |
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| Institution: | Institute of Preventive Veterinary Medicine, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan Province, China;Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan Province, China;Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, Sichuan Province, China,Institute of Preventive Veterinary Medicine, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan Province, China;Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan Province, China;Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, Sichuan Province, China and Institute of Preventive Veterinary Medicine, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan Province, China;Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan Province, China;Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, Sichuan Province, China |
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| Abstract: | Nearly all bacteria require iron for growth and survival. In aerobic environment, ferric iron almost cannot be utilized directly by bacteria. But ferrous iron is mainly existing in the host gastrointestinal. Soluble ferrous iron Fe(II)] is imported directly via membrane transporters into periplasmic, then ferrous iron is imported via ferrous iron transport systems into cytoplasm. Most of gram-negative bacteria uptake ferrous iron by Feo system. The Feo transport system in Escherichia coli consists of the feoA, feoB, and feoC genes. In addition to the Feo transport system, the Yfe transport system and the Efe transport system and the Sit transport system are involved in the transport of ferrous iron. In this review, we described the component and functional mechanism of Feo system in gram-negative bacteria, to provide reference for studying other bacteria ferrous iron transport mechanism. |
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| Keywords: | gram-negative bacteria ferrous iron Feo transport system |
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