BRCA1 is required for postreplication repair after UV-induced DNA damage |
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| Authors: | Pathania Shailja Nguyen Jenna Hill Sarah J Scully Ralph Adelmant Guillaume O Marto Jarrod A Feunteun Jean Livingston David M |
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| Affiliation: | Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. |
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| Abstract: | BRCA1 contributes to the response to UV irradiation. Utilizing its BRCT motifs, it is recruited during S/G2 to UV-damaged sites in a DNA replication-dependent but nucleotide excision repair (NER)-independent manner. More specifically, at UV-stalled replication forks, it promotes photoproduct excision, suppression of translesion synthesis, and the localization and activation of replication factor C complex (RFC) subunits. The last function, in turn, triggers post-UV checkpoint activation and postreplicative repair. These BRCA1 functions differ from those required for DSBR. |
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