Lipid peroxidation in plumbagin administered rats |
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| Authors: | R. Sankar P. S. Devamanoharan G. Raghupathi M. Krishnasamy C. S. Shyamala Devi |
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| Affiliation: | (1) Department of Biochemistry, University of Madras, A. C. College Campus, 600 025 Madras, India;(2) Captain Srinivasa Murti Drug Research Institute for Ayurveda, Arumbakkam, 600 029 Madras, India |
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| Abstract: | ![]()
Plumbagin was administered to rats at a concentration of 1,2,4,8 and 16 mg per kg body weight. After 24 h lipid peroxide levels were found to decrease in subcellular fractions of liver. Plumbagin inhibited ascorbate and nicotinafde adenine dinucleotide phosphate (reduced) dependent lipid peroxidation but was without any effect on cumene hydroperoxide dependent lipid peroxidation. Injection of 16 mg of plumbagin per kg body weight was found to decrease liver total reduced glutathione and also fcrosomal glucose-6-phosphatase. The results are discussed with reference to the anti- and prooxidant properties of plumbagin. |
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| Keywords: | Plumbagin lipid peroxidation glutathione glucose-6-phosphatase |
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