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A mechanistic understanding of production instability in CHO cell lines expressing recombinant monoclonal antibodies |
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| Authors: | Minsoo Kim Peter M. O'Callaghan Kurt A. Droms David C. James |
| Affiliation: | 1. Department of Chemical and Biological Engineering, University of Sheffield, Mappin St., Sheffield S1 3JD, UK;2. telephone: +44‐114‐222‐7505;3. fax: +44‐114‐222‐7501;4. BioTherapeutics Research and Development, Pfizer Corporation, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017 |
| Abstract: | |
| Keywords: | Chinese hamster ovary cells DNA methylation monoclonal antibody production instability |