Prostaglandins and congeners V. (1) Synthesis of d1-prostaglandin E1, d1-11-deoxyprostaglandin E1, and d1-15-hydroxy-9-oxo-13-<math><mtext>cis</mtext></math>-prostenoic acid via conjugate addition of 3-trityloxy-1-octenylmagnesium bromides期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Prostaglandins and congeners V. (1) Synthesis of d1-prostaglandin E₁, d1-11-deoxyprostaglandin E₁, and d1-15-hydroxy-9-oxo-13- $cis$ -prostenoic acid via conjugate addition of 3-trityloxy-1-octenylmagnesium bromides

Authors:	Karel F Bernady Martin J Weiss

Institution:	Process and Analytical Research Section, Lederle Laboratories, American Cyanamid Company, Pearl River, New York 10965, USA

Abstract:	d1-Prostaglandin E₁ and d1-11-deoxyprostaglandin E₁ are conveniently synthesized via the copper (I) catalyzed conjugate addition of the Grignard reagent prepared from 3-trityloxy- $trans$ -1-octenyl bromide to the appropriate cyclopentenone precursor. The Grignard reagent also afforded the synthesis of a novel structure, d1-15-hydroxy-9-oxo-13- $cis$ -prostenoic acid.

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