Neuropeptides and thermoregulation: the interactions of bombesin, neurotensin, TRH, somatostatin, naloxone and prostaglandins |
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| Authors: | J E Morley A S Levine M M Oken M Grace J Kneip |
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| Institution: | 1. Neuroendocrine Research Laboratory, Minneapolis VA Medical Center, Minneapolis, MN 55417 USA;2. Division of Endocrinology, Departments of Medicine and Food Science and Nutrition University of Minnesota, Minneapolis and St. Paul, MN USA;3. Division of Hematology, Departments of Medicine and Food Science and Nutrition University of Minnesota, Minneapolis and St. Paul, MN USA |
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| Abstract: | In this study we have examined the interactions of bombesin (1 microgram ICV), neurotensin (1 microgram ICV), TRH (10 micrograms ICV), somatostatin (10 micrograms ICV), PGE2 (10 micrograms ICV) and naloxone (10 mg/kg SC) on thermoregulation in the rat at room temperature (20 +/- 1 degree C). Given alone, bombesin, neurotensin, somatostatin and naloxone all produced hypothermia (bombesin greater than neurotensin greater than somatostatin congruent to naloxone). PGE2 was hyperthermic, and TRH had no effect. Bombesin and PGE2 neutralized one another's effects. Neurotensin had no effect on PGE2-induced hyperthermia. Naloxone enhanced the hypothermic effect of bombesin and somatostatin enhanced the rate of onset of hypothermia after bombesin. TRH had no effect on bombesin-induced hypothermia. TRH, somatostatin and naloxone had no effect on neurotensin-induced hypothermia. TRH antagonized the hypothermia due to naloxone and somatostatin. |
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| Keywords: | TRH Naloxone Prostaglandins Bombesin Opiates Temperature Neurotensin Somatostatin Hypothalamus |
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