Emerging Roles of Ruk/CIN85 in Vesicle‐Mediated Transport,Adhesion, Migration and Malignancy |
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| Authors: | Serhiy Havrylov Maria Jolanta Redowicz Vladimir L. Buchman |
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| Affiliation: | 1. Nencki Institute of Experimental Biology, Pasteura 3 Street, 02‐093 Warsaw, Poland;2. School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, Wales, UK |
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| Abstract: | ![]()
Ruk/CIN85 is an adaptor protein. Similar to many other proteins of this type, Ruk/CIN85 is known to take part in multiple cellular processes including signal transduction, vesicle‐mediated transport, cytoskeleton remodelling, programmed cell death and viral infection. Recent studies have also revealed the potential importance of Ruk/CIN85 in cancer cell invasiveness. In this review we summarize the various roles of this protein as well as the potential contribution of Ruk/CIN85 to malignancy and the invasiveness of cancer cells. In the last section of the paper we also speculate on the utility of Ruk/CIN85 as a target for novel anti‐cancer therapies. |
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| Keywords: | cancer cell invasion cell adhesion cell migration invadopodia malignancy Ruk/CIN85 vesicle‐mediated transport |
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