Potential antimicrobial agents from triazole-functionalized 2H-benzo[b][1,4]oxazin-3(4H)-ones |
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| Authors: | Rajitha Bollu Saleha Banu Rajashaker Bantu A Gopi Reddy Lingaiah Nagarapu K Sirisha C Ganesh Kumar Shravan Kumar Gunda Kamal Shaik |
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| Institution: | 1. Organic Chemistry Division II (CPC), CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, Telangana, India;2. Medicinal Chemistry and Biotechnology Division (MCB), CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 007, India;3. Bioinformatics Wing, Mycology & Plant Pathology Lab, Department of Botany, Osmania University, Hyderabad 500007, India |
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| Abstract: | A series of substituted triazole functionalized 2H-benzob]1,4]oxazin-3(4H)-ones were synthesized by employing click chemistry and further characterized based on 1H NMR, 13C NMR, IR and mass spectral studies. All the synthesized derivatives were screened for their in vitro antimicrobial activities. Further, molecular docking studies were accomplished to explore the binding interactions between 1,2,3-triazol-4-yl-2H-benzob]1,4]oxazin-3(4H)-one and the active site of Staphylococcus aureus (CrtM) dehydrosqualene synthase (PDB ID: 2ZCS). These docking studies revealed that the synthesized derivatives showed high binding energies and strong H-bond interactions with the dehydrosqualene synthase validating the observed antimicrobial activity data. Based on antimicrobial activity and docking studies, the compounds 9c, 9d and 9e were identified as promising antimicrobial leads. |
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| Keywords: | 1 4-Benzoxazine 1 2 3 Triazoles Antimicrobial activity Molecular docking Dehydrosqualene synthase |
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