Isolation,identification of Streptococcus pneumoniae from infected rhesus monkeys and control efficacy |
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| Authors: | Shasha Zou Qihui Luo Zhengli Chen Anchun Cheng Mingshu Wang Dekang Zhu Renyong Jia Fei Liu Xiaoyue Chen Yi Zhou Fengjun Bi Zexia Yang |
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| Institution: | 1. Key Laboratory of Animal Diseases and Human Health of Sichuan Province, Ya’an, Sichuan, China;2. Epizootic Diseases Institute of Sichuan Agricultural University, Ya’an, Sichuan, China;3. These authors contributed equally to this work and should be consider as first author.;4. National Experimental Macaque Reproduce Laboratory, Engineering and Technology Center for Laboratory Animal of Sichuan Agricultural University, Ya’an, China;5. Key Laboratory of Animal Diseases and Human Health of Sichuan Province, Ya’an, Sichuan, China |
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| Abstract: | Background Streptococcus pneumoniae can cause a wide variety of illnesses. Primate animals can be infected by the pneumococcus. A disease occurred among rhesus monkeys in winter 2006. Methods Routine clinical observation, necropsies, bacteriological examinations were conducted, and PCR, pathogenicity to BALB/c mice and antibiotic susceptibility test were examined additionally. Results We conclude that the agent is S. pneumoniae. Based on the antibiotic susceptibility test, a dose of 20 mg/kg body weight daily of Erythromycin was given intramuscular injection for 5 days, resulting in the disappearance of clinical signs, and no newly case reappear be observed till today. Conclusions Therefore, it is suggested that the outbreak of respiratory disease in the rhesus monkeys was because of transmission of S. pneumoniae among rhesus monkeys. The antibiotic therapy finding underscores the utility of Erythromycin to cure the infected rhesus monkeys without causing side effects and without contributing to the further development of antibiotic resistance. |
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| Keywords: | Streptococcus pneumoniae Rhesus monkey isolated |
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