| 泛素介导的植物膜蛋白转运及其研究方法 |
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| 引用本文： | 苏泊丹,林金星,肖建伟.泛素介导的植物膜蛋白转运及其研究方法[J].植物学报,2016,51(3):387-395. |
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| 作者姓名： | 苏泊丹 林金星 肖建伟 |
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| 作者单位： | 北京林业大学生物科学与技术学院, 北京 100083 |
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| 基金项目： | 中央高校基本科研业务费专项资金(No.BLX2013019)和国家自然科学基金(No.31400210) |
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| 摘 要： | 泛素(Ub)是一类小分子多肽, 可通过赖氨酸残基与靶蛋白结合, 进而决定靶蛋白的去向。泛素分子对靶蛋白进行特异性修饰的过程称为泛素化。相较于动物和酵母细胞, 植物细胞中泛素介导的蛋白动态循环, 尤其是膜蛋白胞吞动态循环研究相对滞后。随着生物化学以及显微技术的发展, 人们对泛素介导的植物细胞膜蛋白转运有了新的认识。该文阐述了泛素及类泛素在蛋白转运中的作用, 总结了泛素化(ubiquitylation)调控膜蛋白转运的分子生物学机制和常用的研究方法, 并对今后该领域的研究进行了展望。
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| 收稿时间： | 2015-06-18 |
Ubiquitin-mediated Membrane Protein Trafficking in Plant Cells and Related Research Techniques: A Review |
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| Bodan Su,Jinxing Lin,Jianwei Xiao.Ubiquitin-mediated Membrane Protein Trafficking in Plant Cells and Related Research Techniques: A Review[J].Bulletin of Botany,2016,51(3):387-395. |
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| Authors: | Bodan Su Jinxing Lin Jianwei Xiao |
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| Institution: | College of Biological Sciences and Technology, Beijing Forestry University, Beijing 100083, China |
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| Abstract: | Ubiquitin is covalently attached to target proteins via a lysine residue to decide the fate of the target proteins. However, the investigations of ubiquitin-mediated protein, especially membrane protein trafficking processes, are few in plant cells as compared with mammal and yeast cells. The application of biochemical techniques and microtechniques provide new tools for dissecting the mechanisms of ubiquitin-mediated membrane protein trafficking in plants. This review summarizes our current understanding of how ubiquitin modification affects membrane protein trafficking, with special emphasis on mechanisms of ubiquitin-mediated membrane protein sorting and related research techniques, which provide valuable information for further study on ubiquitin-mediated membrane protein trafficking in plants. |
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