反义基因治疗

除了反义核酸和核酶外,最近又发展了一种新型的反义药物———反义肽核酸(PNA)。反义治疗的经典策略是阻断异常基因的表达;随着研究的深入,又发现了以反义药物调整基因表达比例(即调控基因治疗)的反义治疗途径。本文对反义基因治疗的策略、反义药物的设计及稳定性等方面的新思路和该领域的发展与应用前景作了概括介绍。

Antisense Gene Therapy

Besides of antisense nucleic acid and ribozyme,a new kind of antisense drug,named antisense peptide nucleic acid (PNA),was recently developed.The classical strategy for antisense therapy is to abrogate abnormal gene expression.However,a new approach by balance the ratio of gene expression was found to be work with the progress of the study in this field.Here we briefly described the new ideas in the strategy of antisense gene therapy,the antisense drug design,the stability of antisense drugs,and the future prospects in this field.;