| 组蛋白去乙酰化酶6:异常蛋白降解的关键调控因子 |
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| 作者姓名： | Su M Sun X Liu CF |
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| 作者单位： | 1. 苏州大学第二附属医院神经内科,苏州,215004
2. 苏州大学第二附属医院神经内科,苏州215004;苏州大学神经科学研究所,苏州,215123 |
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| 基金项目： | 国家自然科学基金资助课题 |
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| 摘 要： | 组蛋白去乙酰化酶6(HDAC6)是位于胞浆中的一种去乙酰化酶,参与调控细胞内多种重要的生物活性,可使α-微管蛋白(α-tubulin)、热休克蛋白90(Hsp90)和皮肌动蛋白(cortactin)去乙酰化,并与多种蛋白质缔结形成复合物。在细胞培养中,当产生的错误折叠蛋白超过了分子伴侣再折叠及泛素蛋白酶体系统(UPS)处理能力时,HDAC6可将其特异转运到细胞核周结构——异常蛋白包涵体(aggresome)中,从而使之被自噬有效降解,因此认为HDAC6在异常蛋白降解中发挥了关键的调控功能,是"蛋白构象病"的潜在治疗靶点。
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| 关 键 词： | 组蛋白去乙酰化酶6 异常蛋白包涵体 自噬 泛素蛋白酶体 |
Histone deacetylase 6: the key regulator of misfolded proteins |
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| Su M,Sun X,Liu CF.Histone deacetylase 6: the key regulator of misfolded proteins[J].Progress in Physiological Sciences,2010,41(2):112-116. |
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| Authors: | Su Min Sun Xue Liu Chun-Feng |
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| Institution: | Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou 215004, China. |
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| Abstract: | Histone deacetylase 6 (HDAC6) is a cytoplasmic enzyme that regulates many important biological processes. It deacetylates α-tubulin, Hsp90 and cortactin, and forms complexes with other partner proteins. When the misfolded proteins are too more to be degradated by the chaperone refolding system and the ubiquitin-proteasome system in cultured cells, misfolded proteins are specifically transported to a cytoplasmic juxtanuclear structure called aggresome by HDAC6, facilitating their clearance by autophagy. The diverse functions of HDAC6 in misfolded proteins degradation pathway suggest that it is a potential therapeutic target for the treatment of "conformational diseases". |
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| Keywords: | aggresome histone deacetylase 6 autophagy ubiquitin-proteasome |
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