自噬蛋白NDP52与细菌感染的研究进展

自噬（autophagy）是哺乳动物清除入侵细菌的主要途径,可保卫宿主细胞免受细菌的损伤。核点蛋白52（nuclear dot protein 52,NDP52）——核点家族成员之一,是除p62/SQSTM1和NBR1等之外最新发现的自噬关键蛋白。它连接自噬体表面的微管相关蛋白1轻链3（microtubule associ-ated protein 1 light chain 3,LC3）,将披上＂泛素大衣＂的病原菌（如沙门氏菌和化脓性链球菌）递送至自噬体内加以清除。这一发现有助于人们深入了解自噬抵抗病原微生物感染的具体分子机制,为预防和治疗细菌感染提供了新靶点。

Research Advances in Autophagy Protein NDP52 and Bacterial Infection

Autophagy is an important pathway to eliminate intracellular bacteria in mammals and defend the host cell from bacteria damage.In addition to p62/SQSTM1 and NBR1,NDP52（nuclear dot protein 52）—one of the members of nuclear dots,is a novel autophagy related protein has been found.NDP52 is an adaptor protein that binds to both ubiquitinated bacteria（such as Salmonella and Streptococcus pyogenes） and LC3（microtubule associated protein 1 light chain 3）,and then delivers these invaders into autophagosomes.This finding helps further understand the specific molecular mechanism of autophagy resisting pathogens infection,and provides a new target for the prevention and treatment of bacteria infection.