| 结核分枝杆菌与巨噬细胞相互作用的研究进展 |
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| 引用本文： | 刘云霞,张万江. 结核分枝杆菌与巨噬细胞相互作用的研究进展[J]. 细胞生物学杂志, 2012, 0(6): 617-622 |
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| 作者姓名： | 刘云霞 张万江 |
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| 作者单位： | 石河子大学医学院,新疆地方与民族高发病教育部重点实验室,石河子832000 |
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| 基金项目： | 国家自然科学基金（No.30960355）; 石河子大学科学技术研究发展计划“自然科学与计划创新”重点项目（No.ZRKX2010ZD01）,石河子大学2010年研究生创新基金项目（No.YJCX2010-Y07）资助项目 |
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| 摘 要： | 结核分枝杆菌（Mycobacterium tuberculosis,MTB）是一种典型的胞内致病菌,巨噬细胞是MTB在体内的主要宿主细胞。巨噬细胞具有强大的吞噬功能,在机体固有免疫和适应性免疫中均发挥着重要作用,可有效保护宿主免受结核分枝杆菌的感染。MTB在与宿主巨噬细胞的长期相互作用过程中,逐渐形成多种逃避杀灭的有效策略,得以在宿主体内存活并增殖。该文从巨噬细胞抗MTB感染及MTB逃避巨噬细胞杀灭两个方面综述国内外的研究进展。
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| 关 键 词： | 结核分枝杆菌 巨噬细胞 凋亡 |
Progress of Interactions between Mycobacterium tuberculosis and Macrophages |
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| Liu Yunxia,Zhang Wanjiang. Progress of Interactions between Mycobacterium tuberculosis and Macrophages[J]. Chinese Journal of Cell Biology, 2012, 0(6): 617-622 |
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| Authors: | Liu Yunxia Zhang Wanjiang |
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| Affiliation: | (Shihezi University School of Medicine,The Key Laboratory of Ministry of Education of Xinjiang Endemic and Ethnic Disease, Shihezi 83200,China) |
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| Abstract: | Macrophages are the main host of Mycobacterium tuberculosis,a kind of typical intracellular pathogen bacteria.Macrophages have a powerful phagocytosis,which plays an important role in both innate immunity and adaptive immunity and can effectively protect host from Mycobacterium tuberculosis infection.In the long-term interaction process with host macrophages,Mycobacterium tuberculosis gradually formed a variety of effective strategies to avoid killing to survive and proliferate in the host.This article from macrophages resistance to Mycobacterium tuberculosis infection and Mycobacterium tuberculosis evading macrophages killing reviewes domestic and international research. |
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| Keywords: | Mycobacterium tuberculosis macrophage apoptosis |
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