| 长链非编码RNA与肿瘤的关系及其临床价值 |
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| 引用本文： | 宋皓军,俞秀冲,夏天,郭俊明,肖丙秀. 长链非编码RNA与肿瘤的关系及其临床价值[J]. 细胞生物学杂志, 2012, 0(7): 704-712 |
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| 作者姓名： | 宋皓军 俞秀冲 夏天 郭俊明 肖丙秀 |
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| 作者单位： | 宁波大学医学院生物化学与分子生物学教研室,宁波315211 |
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| 基金项目： | 国家自然科学基金（No.81171660）、浙江省研究生创新科研项目（No.YK2011046）、宁波市科技创新团队项目（No.2011B82014）和宁波市重点学科项目（No.XKL11D2127）资助项目 |
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| 摘 要： | 长链非编码RNA（long non-coding RNA,IncDNA）是指长度超过200个核苷酸、具有调控基因表达作用的非编码RNA。近年来研究表明,长链非编码RNA在肿瘤的发生、发展过程中发挥着促癌或抑癌作用,它们参与了细胞凋亡调控、肿瘤浸润与转移等过程;另外,它们还通过表观遗传调控的方式影响肿瘤细胞的生长。它们有希望成为新型肿瘤标志物和肿瘤治疗的靶点,在肿瘤诊断和治疗方面显示出良好的临床应用前号。
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| 关 键 词： | 长链非编码RNA 肿瘤 基因表达调控 肿瘤标志物 |
Associations between Long Non-coding RNAs and Tumors, and Their Clinical Values |
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| Song Haojun,Yu Xiuchong,Xia Tian,Guo Junming,Xiao Bingxiu. Associations between Long Non-coding RNAs and Tumors, and Their Clinical Values[J]. Chinese Journal of Cell Biology, 2012, 0(7): 704-712 |
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| Authors: | Song Haojun Yu Xiuchong Xia Tian Guo Junming Xiao Bingxiu |
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| Affiliation: | (Department of Biochemistry, Ningbo University School of Medicine, Ningbo 315211, China) |
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| Abstract: | Long non-coding RNAs （lncRNAs） are a class of non-coding RNAs more than 200 nucleotides in length, which have the functions of gene expression regulations. Recent studies showed that lncRNAs are emerging as new players in the cancer paradigm demonstrating potential roles in both oncogenic and tumor suppressive pathways. They take part in regulations of apoptosis, tumor invasion and metastasis. Besides, they affect tumor cell growth through epigenetic regulations. As the possible novel tumor markers and targets for the treatments of cancers, lncRNAs show a good prospect for the clinical applications in the diagnosis and treatments of several types of cancers. |
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| Keywords: | long non-coding RNAs tumor gene expression regulation tumor marker |
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