|
|||||
|
|
Association between Polymorphism of the Vitamin D Metabolism Gene CYP27B1 and HLA-B27-Associated Uveitis. Is a State of Relative Immunodeficiency Pathogenic in HLA B27-Positive Uveitis? |
|
| Authors: | Gernot Steinwender Ewald Lindner Martin Weger Sophie Plainer Wilfried Renner Navid Ardjomand Yosuf El-Shabrawi |
| Institution: | 1. Department of Ophthalmology, Auenbrugger University Graz, Graz, Austria.; 2. Department of Ophthalmology, Klinikum Klagenfurt, Klagenfurt, Austria.; 3. Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, Graz, Austria.; Medical University Graz, Austria, |
| Abstract: | ObjectivePolymorphisms of the vitamin D metabolism gene CYP27B1 showed associations with multiple autoimmune diseases. The aim of this study was to investigate a possible association between the rs703842 A>G polymorphism of the CYP27B1 gene and HLA-B27-associated uveitis.DesignOne hundred fifty-nine patients with HLA-B27-associated uveitis, 138 HLA-B27-negative controls and 100 HLA-B27-positive controls were recruited for this retrospective case-control study. Main outcome parameters were genotype distribution and allelic frequencies determined by polymerase chain reaction.ResultsCarriers of the rs703842G allele were found significantly more often in patients with HLA-B27-associated uveitis than in HLA-B27-positive controls (p = 0.03). Between patients and HLA-B27-negative controls no significant difference in the genotype distribution of the rs703842 A>G polymorphism was found (p = 0.97).ConclusionsOur data suggest that the rs703842 A>G polymorphism may play a role in HLA-B27-associated uveitis. |
| Keywords: | |