Inhibition of ADP-ribosyltransferase activity of cholera toxin by MDL 12330A and chlorpromazine |
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Authors: | A J Bitonti |
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Institution: | Merrell Dow Research Institute, 2110 E. Galbraith Road, Cincinnati, Ohio 45215 USA |
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Abstract: | ADP-ribosylation by cholera toxin of the guanine nucleotide binding regulatory protein (Gs) of rat liver membrane adenylate cyclase was inhibited by 0.1-1 mM MDL 12330A or 0.1-1 mM chlorpromazine. Basal as well as cholera toxin activated adenylate cyclase activity in liver membranes was also inhibited by the two drugs. NAD glycohydrolase activity and self-ADP-ribosylation of cholera toxin were also inhibited by MDL 12330A and chlorpromazine. These effects of MDL 12330A and chlorpromazine may be related to their effects on cholera toxin-induced fluid secretion in vivo. |
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