Synthesis and preliminary antitumor activity evaluation of a DHA and doxorubicin conjugate |
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| Authors: | Wang Yuqiang Li Lianfa Jiang Wei Yang Zhaoqi Zhang Zaijun |
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| Affiliation: | Institute of New Drug Research, Jinan University College of Pharmacy, Guangzhou 510632, China. yuqiangwang2001@yahoo.com |
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| Abstract: | ![]()
A conjugate of DHA and doxorubicin (DHA-Dox) was synthesized, and its antitumor activity was evaluated in vitro against L1210 leukemia cells and in experimental animal tumor models including L1210 leukemia and B16 melanoma. DHA-Dox showed a greatly improved antitumor efficacy compared to free doxorubicin. |
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