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Surface-Matrix Screening Identifies Semi-specific Interactions that Improve Potency of a Near Pan-reactive HIV-1-Neutralizing Antibody |
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| Authors: | Young D Kwon Gwo-Yu Chuang Baoshan Zhang Robert T Bailer Nicole A Doria-Rose Tatyana S Gindin Bob Lin Mark K Louder Krisha McKee Sijy O’Dell Amarendra Pegu Stephen D Schmidt Mangaiarkarasi Asokan Xuejun Chen Misook Choe Ivelin S Georgiev Vivian Jin Marie Pancera Peter D Kwong |
| Institution: | 1. Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD 20892, USA;2. Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA;3. Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA;4. Los Alamos National Laboratory, Los Alamos, NM 87545, USA;5. Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA;6. Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA |
| Abstract: |  |
| Keywords: | antibody improvement surface-matrix screening HIV-1 broadly neutralizing antibody membrane-proximal external region MPER 10E8 |
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