Tumoricidal responses in vitro of peritoneal macrophages from conventionally housed and germ-free nude mice |
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Authors: | Monte S Meltzer |
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Institution: | Tumor Antigen Section, Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014 USA |
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Abstract: | Peritoneal macrophages from untreated nude mice were nonspecifically cytotoxic to tumor cells in vitro and were more responsive to chemotactic stimuli than macrophages from normal mice or from phenotypically normal littermates of nude mice. Tumoricidal and chemotactic responses of activated macrophages from nude mice were quantitatively comparable to responses of macrophages from BCG-infected normal mice. Peritoneal macrophages from germ-free nude mice, however, were not tumoricidal in vitro. These observations suggest that environmental stimuli, rather than thymic deficiency per se, induced activated macrophages in nude mice. |
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Keywords: | Send reprint requests to Dr Monte S Meltzer Bldg 37 Rm 2C20 National Cancer Institute NIH Bethesda Md 20014 |
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