Adenovirus-mediated expression of BmK CT suppresses growth and invasion of rat C6 glioma cells |
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| Authors: | Jun Du Yuejun Fu Jianing Wang Aihua Liang |
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| Institution: | 1. Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Biotechnology, Shanxi University, Taiyuan, 030006, People’s Republic of China
2. Institute of Clinical Medicine, Hubei University of Medicine, Shiyan, 442000, People’s Republic of China
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| Abstract: | BmK CT, one of the key toxins in the venom of the scorpion, Buthus martensii Karsch, can interact specifically with glioma cells as a chloride channel blocker and inhibit the invasion and migration of those cells via MMP-2. A recombinant adenovirus, Ad-BmK CT, was constructed and characterized by in vitro and in vivo studies, using MTT cytotoxicity assay and the glioma C6/RFP (red fluorescence protein)/BALB/c allogeneic athymic nude mice model, respectively. The adenovirus-mediated expression of BmK CT displayed a high activity in suppressing rat C6 glioma cells growth and invasion thereby suggesting that this recombinant adenovirus may be a powerful method for treating glioblastoma. |
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