Fatty acid composition of brown adipose tissue in genetically heat-tolerant FOK rats |
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| Authors: | T Ohno F Furuyama A Kuroshima |
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| Institution: | (1) Course of Health and Welfare, Hokkaido University of Education, Asahikawa 070-8621, Japan, JP;(2) Department of Physiology, Nagoya City University Medical School, Nagoya 467-8601, Japan, JP;(3) Department of Physiology, Asahikawa Medical College School of Medicine, Asahikawa 078-8510, Japan, JP;(4) Department of Physiology, Asahikawa Medical College School of Medicine, Asahikawa 078-8510, Japan, e-mail:akihiro@asahikawa-med.ac.jp, JP |
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| Abstract: | The phospholipid fatty acid composition of brown adipose tissue (BAT) was examined in inbred heat-tolerant FOK rats and compared
with that in conventional Wistar rats not previously exposed to heat. The FOK rats showed higher unsaturation states, as indicated
by higher levels of polyunsaturated fatty acids and a higher unsaturation index and polyunsaturated fatty acids/saturated
fatty acids ratio. This higher level of unsaturation was characterized by the higher amount of polyunsaturated fatty acids
such as linoleic acid, arachidonic acid and docosahexaenoic acid. It may be concluded that the increased docosahexaenoic acid
level in BAT phospholipids brings about the hyperplasia of BAT, causing an enhancement of its in vivo thermogernic activity
as well as the systemic non-shivering thermogenesis observed in heat-tolerant FOK rats.
Received: 17 May 2000 / Revised: 21 August 2000 / Accepted: 21 September 2000 |
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| Keywords: | FOK rats Brown adipose tissue Fatty acid composition Docosahexaenoic acid (DHA) |
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