|
|||||
|
|
Amplification of a polymorphic dihydrofolate reductase gene expressing an enzyme with decreased binding to methotrexate in a human colon carcinoma cell line, HCT-8R4, resistant to this drug |
|
| Authors: | S Srimatkandada B I Schweitzer B A Moroson S Dube J R Bertino |
| Institution: | Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510. |
| Abstract: | |
| Keywords: | |