Cytochrome P-450 and parathion metabolism in the fetal and adult gonads of the horse. |
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| Authors: | G Martínez-Zedillo C Castilho-Alonso V M Magdaleno A González-Angulo |
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| Affiliation: | 1. Subjefatura de Investigación Científica, Centro Médico Nacional, Instituto Mexicano del Seguro Social. México City, México;7. Instituto de Ciencias Biomédicas de Universidade de Sao Paulo, Departamento de Fisiología e Farmacología, Bolsista de Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, Brazil |
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| Abstract: | Mixed function oxidase-catalyzed dearylation of parathion was determined in microsomal fractions of gonadal and liver tissues of fetal and adult horse. When parathion metabolism was calculated on a basis of milligram of protein, the activity was found to be similar between fetal and adult gonads but not liver. However, on a basis of nmoles of cytochrome P-450, parathion metabolism was similar between fetal and adult liver but not gonadal tissues; the metabolism being 20 times higher in the adult than the fetal gonad. |
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