| 哺乳动物昼夜节律组构中的下丘脑视交叉上核和松果腺 |
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| 作者姓名： | Zhou XJ Yu GD Yin QZ |
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| 作者单位： | 苏州大学医学院基础医学系神经生物学研究室, |
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| 基金项目： | 国家自然科学基金资助课题(39770246) |
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| 摘 要： | 哺乳动物下丘脑视交叉上核（SCN）是昼夜节律最主要的起搏器,控制着机体的生理和行为的节律。它具有自身内在的节律性,同时也受光照周期信号和一些内源性化学物质的调节。检查腺分泌裉黑素（MEL）受SCN的调控,MEL通过作用于SCN上高亲和性MEL受体,启动第二、第三信使系统,调整SCN的昼夜节律活动。这种调整具有时间敏感性。
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| 关 键 词： | 视交叉上核 松果腺 褪黑素 昼夜节律 哺乳动物 下丘脑 |
The hypothalamic suprachiasmatic nucleus and pineal gland in the circadian rhythmic organization of mammals |
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| Zhou XJ,Yu GD,Yin QZ.The hypothalamic suprachiasmatic nucleus and pineal gland in the circadian rhythmic organization of mammals[J].Progress in Physiological Sciences,2001,32(2):116-120. |
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| Authors: | Zhou X J Yu G D Yin Q Z |
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| Institution: | Laboratory of Neurobiology, Department of Basic Medicine, Medical College of Suzhou University, Suzhou 215007. |
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| Abstract: | WT5BZ]The hypothalamic suprachiasmatic nucleus (SCN) is a most important circadian pacemaker, which controls physiological and behaviour rhythm in mammals. SCN owns a intrinsic rhythm itself, and is entrained by photoperiodic signal and some endogenous chemical substances. Melatonin (MEL) is secreted by pineal gland, which is regulated by SCN. MEL triggers the second and third message systems, and regulates SCN circadian activity through high affinity MEL receptor within SCN. This regulation is time sensitive. |
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| Keywords: | Suprachiasmatic nucleus Pineal gland Melatonin Circadian rhythm |
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