Ixodes ricinus tick saliva modulates tick-borne encephalitis virus infection of dendritic cells |
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| Authors: | Anna Fialová Zdeněk Cimburek Giandomenica Iezzi Jan Kopecký |
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| Institution: | 1. Faculty of Science, University of South Bohemia in ?eské Budějovice, Budweis, Czech Republic;2. Laboratory of Genomics and Proteomics of Disease Vectors, Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Budweis, Czech Republic;3. Section of Vector Biology, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA;4. Department of Clinical Pathobiochemistry, Technische Universität Dresden, Dresden, Germany;5. Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA;1. Yale University School of Medicine, New Haven, CT, United States;2. Howard Hughes Medical Institute, Chevy Chase, MD, United States |
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| Abstract: | Tick-borne encephalitis virus is an important human pathogen, naturally delivered into host skin via a tick bite. To examine the effects of the virus on dendritic cell biology, we cultured dendritic cells with two tick-borne encephalitis virus strains of different virulence in the presence of Ixodes ricinus tick saliva. Tick saliva treatment increased proportion of virus-infected cells, led to a decrease in virus-induced TNF-α and IL-6 production and to reduced virus-induced apoptosis. Our data indicate that tick saliva modulate virus-mediated alterations in dendritic cells, thus probably being involved in the early infection process in the host. |
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