The effect of hyper and hypothyroidism, hypophysectomy and adrenalectomy on phosphatidylethanolamine methyltransferase, phosphatidyldimethyl-ethanolamine methyltransferase and choline phosphotransferase of rat liver microsomes |
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| Authors: | W E Cornatzer D R Hoffman J A Haning |
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| Affiliation: | 1. Department of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University, Athens 17676, Greece;2. Department of Nutrition and Dietetics, School of Physical Education, Sports and Dietetics, University of Thessaly, Trikala 38221, Greece;3. First Cardiology Clinic, Medical School, National and Kapodistrian University of Athens, Hippokration Hospital, Athens 15772, Greece;4. First Department of Propaedeutic Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, Athens 15772, Greece;1. Department of Obstetrics and Gynaecology, Aga Khan University, P.O. Box 38129, Dar Es Salaam, Tanzania;2. Department of Family Medicine, Aga Khan University, P.O. Box 38129, Dar Es Salaam, Tanzania;3. Department of Radiology, Aga Khan Hospital, P.O. Box 2289, Dar Es Salaam, Tanzania;1. Universidade de Brasília, Programa de Pós-Graduação em Botânica, Campus Darcy Ribeiro Departamento de Botânica, CEP: 7091-900 Brasília, DF, Brazil;2. Universidade Federal do Rio de Janeiro, Museu Nacional, Departamento de Botânica, Laboratório de Palinologia, Quinta da Boa Vista, São Cristovão, 20940-040 Rio de Janeiro, RJ, Brazil;3. Universidade Estadual de Feira de Santana, Departamento de Ciências Biológicas, Laboratório de Micromorfologia Vegetal, CEP: 44031-460 Feira de Santana, BA, Brazil;4. Embrapa Recursos Genéticos e Biotecnologia, Parque Estação Ecológica, Final W5 Norte, C. Postal 02372, 70770-900 Brasília, DF, Brazil |
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| Abstract: | ![]()
The effect of hyper- and hypothyroid, hypophysectomy and adrenalectomy on phosphatidylcholine biosynthetic enzymes, phosphatidylethanolamine methyltransferase, phosphatidyldimethylethanolamine methyltransferase and choline phosphotransferase of liver microsomes was measured in rats. There was a significant increase in the specific activity of phosphatidylethanolamine methyltransferase in the hyperthyroid rats. There was a significant reduction in the specific activity of phosphatidylethanolamine methyltransferase and phosphatidyldimethylethanolamine methyltransferase in the hypothyroid states. The choline phosphotransferase increased significantly in the hyperthyroid state and decreased in the hypothyroid animals. Hypophysectomy resulted in a significant increase in specific activity of choline phosphotransferase. A reduction in the specific activity of the phosphatidylethanolamine methyltransferase occurred after 28 days of hypophysectomy. Adrenalectomy resulted in a significant stimulation of the specific activity of phosphatidylethanolamine methyltransferase and choline phosphotransferase in liver microsomes. |
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