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Genetic heterogeneity of early-onset familial breast cancer |
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| Authors: | Hagay Sobol Sylvie Mazoyer Steven A Narod Simon A Smith Donald M Black Pierre Kerbrat Béatrice Jamot Ellen Solomon Bruce A J Ponder Dominique Guerin |
| Institution: | (1) Oncology-Genetics Unit, Centre Léon Bérard, 28, Rue Laënnec, 08 Lyon Cedex, France;(2) Division of Medical Genetics, McGill University, Montreal, Canada;(3) Department of Pathology, University of Cambridge, Cambridge, UK;(4) Somatics Cell Genetics, Imperial Cancer Research Fund Laboratories, London, UK;(5) Department of Medecine, Centre Eugène Marquis, Rennes, France |
| Abstract: | Summary A gene for early-onset familial breast cancer has recently been mapped to the chromosome 17q12–23 region. In order to confirm the gene location, we have tested an extensive early-onset breast cancer family with 4 markers in this chromosome region. Linkage was negative with all 4 markers. This study suggests that there is genetic heterogeneity among early-onset breast cancer families. |
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