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Comparative XANES study of serotransferrin and ovotransferrin at Cu K-edge: evidence of interactions among the metal sites |
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| Authors: | F Boffi I Ascone A Varoli Piazza M Girasole S Della Longa A Giovannelli A Congiu Castellano |
| Institution: | (1) Dipartimento di Fisica and INFM, Università La Sapienza Piazzale A. Moro, 00185, Roma;(2) L.U.R.E., CNRS, Commissariat à l'Energie Atomique, MEN, Batiment 209D, 91405 Orsay, France;(3) ISM- CNR Tor Vergata and INFM, Università di Roma `La Sapienza', Roma;(4) Dipartimento di Medicina Sperimentale and INFM, Università dell'Aquila, 67100 L'Aquila |
| Abstract: | The Cu site structure of human serotransferrin and hen ovotransferrin using XANES spectroscopy has been investigated. Although the transferrin family proteins have been extensively studied, the results reported herein are the first concerning the structure of the metal site in C-terminal and N-terminal in the whole protein. Our structural data show that these proteins differ with regard to the independence of the two binding sites and the geometry of copper coordination, ranging from a poorly to a significantly distorted octahedron. |
| Keywords: | copper site synchrotron radiation transferrins X-ray spectroscopy |
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